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Ed Boyden

Y. Eva Tan Professor in Neurotechnology, MIT · Investigator, McGovern Institute and Howard Hughes Medical Institute · Breakthrough Prize and Canada Gairdner International Award winner

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Ed Boyden portrait
How do you innovate where there are no rules or precedents to follow? Ed Boyden built the tools to map the human brain, and he shows leaders how to tackle problems no one has solved before.
Cambridge, United States
Videos

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2017 - Future of Genomic Medicine - Ed Boyden

Bio

About Ed Boyden

Whether you are a scientist or a CEO, solving seemingly intractable problems is central to innovation and leadership. Ed Boyden faced a problem for which there was no precedent: revealing the secrets of the human brain. He led a team that discovered a way to enlarge microscopic parts of the brain so they could be viewed and analyzed, a technique with implications far beyond his own field. He now advises leaders and teams across industries on generating innovation through collaboration across disciplines.

A solutions-driven scientist and entrepreneur, Boyden is co-founder of Cognito Therapeutics, which designs visual and auditory stimuli intended to treat Alzheimer's patients. In 2021, the company reported that its gamma frequency neuro-modulation methods significantly reduced brain atrophy in Alzheimer's patients. His work draws on his group's invention of expansion microscopy and the reverse process of shrinking objects to the nanoscale, advances that he treats as a template for tackling big problems from different angles.

Topics

Ed's Keynote Topics

Wrestling with incredibly complex problems is par for the course in most industries – from finance to health care, education to strategic management. But it is equally common for firms to approach innovation blindly, developing products and services without a roadmap or guide on how to do so. Ed Boyden is a scientific prodigy who pursued his life’s work in a field where breakthroughs are rare and much of the discipline remains a mystery: neuroscience. Yet, he’s succeeding. He built and led a team to develop radical new techniques for mapping and analyzing the brain, potentially ushering in a new era of medical advancement in treating incurable diseases like Alzheimer’s and depression. His team’s development of ways to expand microscopic objects – and subsequently to shrink objects – can have an impact in fields outside his own, potentially revolutionizing our ability to treat diseases like cancer or better understand the origins of human emotions. Often, the solutions were derived from connecting the dots between fields that don’t typically communicate or were figured out by systematic critical thinking methods. In a culture that is knowledge-rich and wisdom-poor, Boyden teaches methods of creativity and imagination that lead to innovative breakthroughs. The techniques learned by trial and error are applicable to every industry, says Boyden – not just science and medicine. In this bold, thought-provoking presentation, he reveals a set of rules for pioneering solutions where there are few rules or precedents to follow.

More than one billion people worldwide suffer from brain diseases like Alzheimer’s, depression, schizophrenia and stroke, often robbing them of their identity and changing how they interact with loved ones. But Ed Boyden believes there is reason to be optimistic about solving such global epidemics. By enlarging parts of the brain through expansion microscopy and controlling their dynamics through optogenetics, Boyden and his team at MIT have analyzed previously unseen details of the organ and prototyped new repair strategies. This work could trigger some of the most important breakthroughs in the history of medical science, extending beyond treating disease to reaching a greater philosophical understanding of how the human mind works, and potentially unlocking unknown mental capabilities that lie buried in our labyrinths of grey matter. In this presentation, Boyden explains how these technologies work, how far he is in the process of realizing his goals and the full impact that such achievements would have for humanity.

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